Achieving normoglycemia is the goal of diabetes therapy and of the scientists working in this field.
There are potentially various ways to reach that goal, including the transplantation of cells exhibiting glucose responsive insulin secretion. However, to be applicable to the large number of people who might benefit from cell replacement, an unlimited supply of cells must be found. To address this problem, we have been developing cell lines from the human endocrine pancreas.
In one case, a cell line of a certain type has been developed from actual human islets that can be induced under some circumstances to differentiate into functional cells exhibiting appropriate glucose responsive insulin secretion.
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